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the agency has issued safety alerts about unlicensed injectable peptides from unregulated sources due to risks of contamination, uncertain potency, and absent stability data

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Importantly, the resultant gene profile from GLP-1–treated hepatocytes—increased mRNA for both PPAR α and AOX—along with decreased mRNA expression for SCD-1, SREBP-1c, and ACC, raises the speculation that GLP-1 impairs hepatocyte de novo lipogenesis and/or enhances β -oxidation of fatty acids